Optimization of [89Zr]ZrCl4 production and purification for high resolution PET imaging

Optimization of [89Zr]ZrCl4 production and purification for high resolution PET imaging

Walther, M.; Gebhardt, P.; Würbach, L.; Irmler, I.; Grosse-Gehling, P.; Preusche, S.; Opfermann, T.; Kamradt, T.; Saluz, H.-P.; Steinbach, J.

Abstract

The exchange of solvent and anions from [89Zr]Zr-oxalate in oxalic acid to [89Zr]ZrCl4 in HCl is a crucial step in the production of 89Zr. A fast and reproducible method using cation instead of anion exchange resin giving a recovery of 98.5 ± 1.1% is described here. Obtained 89Zr was used for labeling a monoclonal antibody directed against CD4+ T helper cells.

Beteiligte Forschungsanlagen

  • PET-Zentrum
  • Poster
    International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy
  • Abstract in referierter Zeitschrift
    Nuclear Medicine and Biology 37(2010)6, 697
    DOI: 10.1016/j.nucmedbio.2010.04.032
  • Beitrag zu fremdem Sammelwerk
    Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 259-260

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