Versatile new bifunctional chelators for copper radionuclides
Versatile new bifunctional chelators for copper radionuclides
Stephan, H.; Bergmann, R.; Steinbach, J.; Spiccia, L.; Comba, P.
Abstract
Three new bifunctional chelating agents (BFCAs) I III have been prepared. These ligands can be efficiently radiolabeled with 64CuII under mild conditions. The carboxylate and alcohol substituents allow to introduce appropriate biomolecules, e.g. peptides such as bombesin and neurotensin by amide coupling. The new BFCAs were found to be hydrophilic and therefore are attractive candidates for developing new copper(II)-based radiopharmaceuticals.
Keywords: TACN; bispidine; cyclam; bifunctional chelating agents; copper-64
Involved research facilities
- PET-Center
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Poster
International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy -
Abstract in refereed journal
Nuclear Medicine and Biology 37(2010)6, 695
DOI: 10.1016/j.nucmedbio.2010.04.086 -
Contribution to external collection
Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 241-242
Permalink: https://www.hzdr.de/publications/Publ-14304