Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors
Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors
Al-Hourani, B. J.; Sharma, S. K.; Mane, J. Y.; Tuszynski, J.; Baracos, V.; Kniess, T.; Suresh, M.; Pietzsch, J.; Wuest, F.
Abstract
A series of 1,5-diaryl-substituted tetrazole derivatives was synthesized via conversion of readily available diaryl amides into corresponding imidoylchlorides followed by reaction with sodium azide. All compounds were evaluated by cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles 3a–e showed IC50 values ranging from 0.42 to 8.1 mM for COX-1 and 2.0 to 200 lM for COX-2. Most potent compound 3c (IC50 (COX-2) = 2.0 lM) was further used in molecular modeling docking studies.
Keywords: Cyclooxygenase; COX-2 inhibitors; 1,5-Diaryl-tetrazoles
Beteiligte Forschungsanlagen
- PET-Zentrum
-
Bioorganic & Medicinal Chemistry Letters 21(2011), 1823-1826
DOI: 10.1016/j.bmcl.2011.01.057
ISSN: 0960-894X
Cited 82 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-15490