Synthesis and crystal structure of benzyl[(1S)-1-(5-amino-1,3,4-oxadiazol-2-yl)-2-phenylethyl]carbamate
Synthesis and crystal structure of benzyl[(1S)-1-(5-amino-1,3,4-oxadiazol-2-yl)-2-phenylethyl]carbamate
Löser, R.; Nieger, M.; Gütschow, M.
Abstract
The conversion of Z-phenylalanine hydrazide with cyanogen bromide resulted in the formation of the corresponding 2-amino-1,3,4-oxadiazole by spontaneous cyclization of the intermediary cyanohydrazide. The molecular structure of the product was confirmed by single crystal X-ray diffraction. Crystals of the title compound where obtained from a saturated solution in a mixture of petroleum ether and ethyl acetate and belong to the monoclinic space group P21 with unit cell parameters a =
9.8152(2) Å, b = 9.6305(2) Å, c = 9.8465(2) Å, beta = 116.785 (1)°. The asymmetric unit contains one molecule.
Keywords: 1,3,4-oxadiazoles; cyanohydrazides; hydrogen bonds; edge-to-face interactions
Beteiligte Forschungsanlagen
- PET-Zentrum
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Crystals 2(2012), 1201-1209
DOI: 10.3390/cryst2031201
ISSN: 2073-4352
Cited 3 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-17354