18F-labelled CCR1-receptor antagonist is not suitable for imaging of Alzheimer's disease
18F-labelled CCR1-receptor antagonist is not suitable for imaging of Alzheimer's disease
Beuthien-Baumann, B.; Holthoff, V.; Mäding, P.; Bergmann, R.; Pawelke, B.; Holl, G.; von Kummer, R.; Kotzerke, J.; van den Hoff, J.
Abstract
Diagnosis of Alzheimer’s disease (AD) with positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) relies on typical alterations of brain glucose metabolism which are, however, not disease specific. Amyloid-β imaging has not entered clinical routine yet. Post mortem histological specimen of brain tissue from AD patients revealed enhanced expression of the chemotactic cytocine receptor 1 (CCR1). Participants, methods: CCR1-antagonist ZK811460 was labeled with fluorine-18 to explore its possible use as specific diagnostic tool in AD. Tracer characterization comprising PET imaging of brain and metabolite analysis was performed in AD patients and controls.
Results: Neither qualitative evaluation nor quantitative compartment analysis of PET data did show any enhanced binding of the 18F-labeled CCR1-antagonist in the brain of AD patients or controls.
Conclusion: 18F-ZK811460 did not fulfill the expectation as diagnostic tracer in PET imaging of AD.
Keywords: Alzheimer’s disease; Positron emission tomography; CCR1 receptor antagonist
Beteiligte Forschungsanlagen
- PET-Zentrum
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Nuklearmedizin 51(2012), 239-243
DOI: 10.3413/Nukmed-0457-12-01
ISSN: 0029-5566
Cited 1 times in Scopus
Permalink: https://www.hzdr.de/publications/Publ-17501