Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy

Petr, Jan; Hofheinz, Frank; Gommlich, Andreas; Raschke, Felix; Troost, Esther; Beuthien-Baumann, Bettina; Seidlitz, Annekatrin; Platzek, Ivan; Baumann, Michael; Krause, Mechthild; Hoff, Jörg van den

Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy

Petr, J.; Hofheinz, F.; Gommlich, A.; Raschke, F.; Troost, E.; Beuthien-Baumann, B.; Seidlitz, A.; Platzek, I.; Baumann, M.; Krause, M.; van den Hoff, J.

Abstract

Gray matter (GM) atrophy in healthy brain tissue following radiochemotherapy was shown in brain-tumor patients in several studies. Here, we aimed to study GM and white matter (WM) changes in glioblastoma patients undergoing photon (n=43) and proton (n=12) radiochemotherapy. In photon-therapy patients, a statistically significant decrease of both GM (~2%) and WM (1.3-2.3%) volume was found with a positive influence of the RT-dose on the GM volume loss. In proton-therapy patients, no significant changes in GM and WM volumes were observed after therapy. This indicates that the proton-therapy has the potential to reduce structural GM changes in healthy tissue.

Keywords: radiochemotherapy; proton therapy; atrophy; morphometrics

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Beitrag zu Proceedings
25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.-27.04.2017, Honolulu, Hawaii, USA
Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy
Vortrag (Konferenzbeitrag)
25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.04.2017, Honolulu, Hawaii

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