P1802 - Universal Building Blocks for Radiolabeling
P1802 - Universal Building Blocks for Radiolabeling
Abstract
The present invention describes novel chelators (multidentate ligands) and precompounds for complexation of radiometals and non-radioactive counterparts, for use in radiopharmacy. The invention includes a process and a kit involving such chelators.
Active moieties directing to a pharmaceutical target (such as peptides or proteins) can be attached to the chelator very easily via the so called “click-chemistry” forming a triazole-ring moiety. The aromatic triazole-nitrogen itself acts as a new and “soft” nucleophilic site enabling for complexation of various radiometals or non-radioactive counterparts. The chelators are capable of fast complexation at low temperature.
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Patent
PCT/EP2019/054954 - Offenlegung 06.09.2019; Nachanmeldungen: EP
Permalink: https://www.hzdr.de/publications/Publ-31180