Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population
Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population
Padrela, B. E.; Lorenzini, L.; Collij, L. E.; Ten Kate, M.; Den Braber, A.; Tomassen, J.; van Berckel, B.; Visser, P. J.; Barkhof, F.; Petr, J.; Mutsaerts, H. J. M. M.
Abstract
Recent findings suggest additive effects of cerebrovascular disease and Alzheimer's disease (AD) on cognitive decline. MR imaging of cerebral blood flow holds great promise as an early dementia biomarker. Supply and demand of blood flow in the brain can be affected by, respectively, the loss of vascular health and the decrease of neuronal activity, as a consequence of AD. This study investigates to what extent vascular and AD components affect CBF and how they interact with each other.
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Permalink: https://www.hzdr.de/publications/Publ-34735
