Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC – Hypothesis generation on a multicentre cohort of the DKTK-ROG

Löck, Steffen; Linge, Annett; Lohaus, Fabian; Ebert, Nadja; Gudziol, Volker; Nowak, Alexander; Tinhofer, Ingeborg; Kalinauskaite, Goda; Guberina, Maja; Stuschke, Martin; Balermpas, Panagiotis; von der Grün, Jens; Grosu, Anca-Ligia; Debus, Jürgen; Ganswindt, Ute; Belka, Claus; Peeken, Jan C.; Combs, Stephanie E.; De-Colle, Chiara; Zips, Daniel; Baretton, Gustavo B.; Krause, Mechthild; Baumann, Michael

doi:10.1016/j.radonc.2022.02.009

Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC – Hypothesis generation on a multicentre cohort of the DKTK-ROG

Löck, S.; Linge, A.; Lohaus, F.; Ebert, N.; Gudziol, V.; Nowak, A.; Tinhofer, I.; Kalinauskaite, G.; Guberina, M.; Stuschke, M.; Balermpas, P.; von der Grün, J.; Grosu, A.-L.; Debus, J.; Ganswindt, U.; Belka, C.; Peeken, J. C.; Combs, S. E.; De-Colle, C.; Zips, D.; Baretton, G. B.; Krause, M.; Baumann, M.

Abstract

Purpose: To develop prognostic biomarker signatures for patients with locally advanced head and neck
squamous cell carcinoma (HNSCC) treated by primary radiochemotherapy (RCTx) based on previously
published molecular analyses of the retrospective biomarker study of the German Cancer Consortium
– Radiation Oncology Group (DKTK-ROG).

Keywords: HNSCC; Biomarkers; Primary radiochemotherapy; Validation; Signature

Radiotherapy and Oncology 169(2022), 8-15
DOI: 10.1016/j.radonc.2022.02.009
Cited 5 times in Scopus

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