Versatile new bifunctional chelators for copper radionuclides

Versatile new bifunctional chelators for copper radionuclides

Stephan, H.; Bergmann, R.; Steinbach, J.; Spiccia, L.; Comba, P.

Abstract

Three new bifunctional chelating agents (BFCAs) I – III have been prepared. These ligands can be efficiently radiolabeled with 64CuII under mild conditions. The carboxylate and alcohol substituents allow to introduce appropriate biomolecules, e.g. peptides such as bombesin and neurotensin by amide coupling. The new BFCAs were found to be hydrophilic and therefore are attractive candidates for developing new copper(II)-based radiopharmaceuticals.

Keywords: TACN; bispidine; cyclam; bifunctional chelating agents; copper-64

Beteiligte Forschungsanlagen

  • PET-Zentrum
  • Poster
    International Symposium on Technetium and other Radiometals in Chemistry and Medicine, 08.-11.09.2010, Bressanone, Italy
  • Abstract in referierter Zeitschrift
    Nuclear Medicine and Biology 37(2010)6, 695
    DOI: 10.1016/j.nucmedbio.2010.04.086
  • Beitrag zu fremdem Sammelwerk
    Ulderico Mazzi, William V. Eckelman, Wynn A. Volkert: Technetium and Other Radiometals in Chemistry and Medicine, Padova: SGEditoriali, 2010, 241-242

Permalink: https://www.hzdr.de/publications/Publ-14304