Publikationsrepositorium - Helmholtz-Zentrum Dresden-Rossendorf

In recent years polynuclear metal complexes have become increasingly important due to their antitumoral as well as antiviral properties. _[1] Their wide variety of biochemical, chemical and physical properties gives the opportunity to create tailor-made drugs. In this perspective, the enhancement of the hydrolytic stability and in particular the improvement of the in vivo selectivity of inorganic cluster compounds represents the major burden to circumvent.

Appropriate nanocontainers may be utilized to enable the cluster compounds to be transported and released within target tissues. Of great interest is the encapsulation of potential drug molecules by non-covalent binding at the interior of dendritic structures which provide well-defined cavities. In this context, dendritic nanocontainer with maltose-modified shell _[2] appears appealing to act as a host for nanometer sized anionic rhenium cluster compounds.

The inclusion and release phenomena of an octahedral rhenium cluster with six terminal hydroxo ligands [Re⁶S⁸(OH)⁶]_{4- [3]} into poly(propylene amine) dendrimers (POPAM, generation 4 and 5) with dense maltose shell have been studied in detail applying different physico-chemical methods, e.g. UV/vis, time-resolved laser-induced fluorescence spectroscopy (TRLFS) and laser induced liquid bead ion desorption (LILBID) mass spectrometry.

On average, 4 – 5 cluster anions can be captured in the interior of the investigated sugar-coated dendrimers, and a slow release of cluster complexes was observed under physiological conditions.

Altogether, the studied system shows the possibility for the development of dendritic nanocarriers with specific targeting and paves the way for therapeutic applications.

[1] J. T. Rhule, C. L. Hill, D. A. Judd, R. F. Schinazi, Chem. Rev.1998, 98, 327-357.
[2] B. Klajnert, D. Appelhans, H. Komber, N. Morgner, S. Schwarz, S. Richter, B. Brutschy, M. Ionov, A. K. Tonkikh, M. Bryszewska, B. Voit, Chem. Eur. J. 2008, 14, 7030.
[3] K. A. Brylev, Y. V. Mironov, S. S. Yarovoi, N. G. Naumov, V. E. Fedorov, S.-J. Kim, N. Kitamura, Y. Kuwahara, K. Yamada, S. Ishizaka, Y. Sasaki, Inorg. Chem. 2007, 46, 7414-7422.