Evaluation of hemodynamic impairments in healthy elderly participants and patients with high-grade unilateral carotid artery stenosis

Kaczmarz, Stephan; Göttler, Jens; Griese, Vanessa; Petr, Jan; Ven, Kim van de; Helle, Michael; Kooijman, Hendrick; Kluge, Anne; Karampinos, Dimitrios; Zimmer, Claus; Sorg, Christian; Preibisch, Christine

Evaluation of hemodynamic impairments in healthy elderly participants and patients with high-grade unilateral carotid artery stenosis

Kaczmarz, S.; Göttler, J.; Griese, V.; Petr, J.; van de Ven, K.; Helle, M.; Kooijman, H.; Kluge, A.; Karampinos, D.; Zimmer, C.; Sorg, C.; Preibisch, C.

Abstract

Internal carotid-artery stenosis (ICAS) causes complex and not yet well understood physiological impairments. We present preliminary data from an ongoing clinical study in ICAS patients and healthy, age-matched participants. The major aims were to evaluate the reliability of a multimodal MRI-protocol and investigate physiological changes. For ICAS patients, regionally impaired vascular-reactivity as well as hypo-perfusion were found. In accordance with literature, we did not find ICAS-induced changes in oxygen extraction on group level. The presented preliminary results thus imply successful application of multimodal MRI methods and are highly promising with respect to gaining a deeper insight into ICAS-related physiological changes.

Keywords: stenosis; ASL; perfusion; MRI

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Beitrag zu Proceedings
25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.-27.04.2017, Honolulu, Hawaii, USA
Proceedings of the 25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine
Vortrag (Konferenzbeitrag)
25th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine, 22.04.2017, Honolulu, Hawaii, USA

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