Activity-Based Probes for Tumour-Associated Transglutaminase 2: From Potent and Selective Inhibitors to Radiotracers
Activity-Based Probes for Tumour-Associated Transglutaminase 2: From Potent and Selective Inhibitors to Radiotracers
Löser, R.
Abstract
The talk is covering the efforts of our group in the development of inhibitor-based radiotracers for the imaging of tumour-associated transglutaminase 2 (TGase 2). Major emphasis will be put on interesting structure-activity relationships of N6-acryloyllysine-derived inhibitors. In addition, general principles for targeting of TGase 2 by irreversible inhibitors will be highlighted. Labelling of these compounds with fluorine-18 and initial results towards their radiopharmacological evaluation will be presented.
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Invited lecture (Conferences)
Gordon Research Conference "Transglutaminases in Human Disease Processes", 17.-22.06.2018, Les Diablerets, Schweiz
Permalink: https://www.hzdr.de/publications/Publ-27883