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1 PublikationDestabilization of DNA through interstrand crosslinking by UO22+
Rossberg, A.; Abe, T.; Okuwaki, K.; Barkleit, A.; Fukuzawa, K.; Nakano, T.; Mochizuki, Y.; Tsushima, S.
Abstract
UO22+ forms an interstrand crosslink between two different strands from a single DNA, which hardly affects the hydrogen bonds between nucleobase pairs whereas it destabilizes the π–π stacking between the two nucleobases in the vicinity of UO22+– bound phosphate. Thereby, fragility of DNA backbone increases upon UO22+ binding.
Keywords: Fragment molecular orbital method; DNA; chemotoxicity; uranyl(VI); interstrand crosslink; EXAFS
Beteiligte Forschungsanlagen
- Rossendorf Beamline an der ESRF DOI: 10.1107/S1600577520014265
Verknüpfte Publikationen
- DOI: 10.1107/S1600577520014265 is cited by this (Id 28053) publication
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Chemical Communications 55(2019), 2015-2018
DOI: 10.1039/C8CC09329F
Cited 11 times in Scopus
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Permalink: https://www.hzdr.de/publications/Publ-28053
