Droplet-based magnetofluidic platforms for detection and analytics

The development of next-generation biosensing technologies has picked up momentum in the past decade. Particularly, among a variety of biosensing principles, magnetic biosensing technologies based on magnetic particles and magnetic field sensors have attracted growing attention due to the unprecedented advantages brought by this unique sensing format.
Our contribution to this exciting field of research and technology includes the development of a compact droplet-based magnetofluidic platform encompassing integrated novel functionalities, e.g. analytics in a flow cytometry format [1-3], magnetic barcoding [4] and sorting of magnetically encoded emulsion droplets [5,6]. We put forth a novel high-capacity indexing scheme based on multiphase microfluidic networks for large-scale screening applications [5,6] and realized flexible microfluidic platform with integrated magnetoresistive sensorics [4]. The technology on how to integrate high-performance magnetic field sensors into multi-functional self-assembled tubular architectures [7-9] for lab-in-a-tube concept [10] will be discussed. These features are crucial to address the needs of modern medical research, e.g. drug discovery [11].
These developments will be outlined in my talk.

[1] G. Lin, D. Makarov et al., “Magnetoresistive emulsion analyzer”. Sci. Rep. 3, 2548 (2013).
[2] G. Lin, D. Makarov et al., “Magnetofluidic platform for multidimensional magnetic and optical barcoding of droplets”. Lab Chip 15, 216 (2015).
[3] D. Karnaushenko, D. Makarov et al., “Monitoring microbial metabolites using an inductively coupled resonance circuit”. Sci. Rep. 5, 12878 (2015).
[4] G. Lin, D. Makarov et al., “A highly flexible and compact magnetoresistive analytic device”. Lab Chip 14, 4050 (2014).
[5] G. Lin, D. Makarov et al., “Magnetic suspension array technology: Controlled synthesis and screening in microfluidic networks”. Small 12, 4553 (2016).
[6] W. Song, D. Makarov et al., “Encoding micro-reactors with droplet chains in microfluidics”. ACS Sensors 2, 1839 (2017).
[7] I. Mönch, D. Makarov et al., “Rolled-up magnetic sensor: Nanomembrane architecture for in-flow detection of magnetic objects”. ACS Nano 5, 7436 (2011).
[8] D. Karnaushenko, D. Makarov et al., “Self-assembled on-chip integrated giant magneto-impedance sensorics”. Adv. Mater. 27, 6582 (2015).
[9] T. Ueltzhöffer, D. Makarov et al., “Magnetically patterned rolled-up exchange bias tubes: A paternoster for superparamagnetic beads”. ACS Nano 10, 8491 (2016).
[10] E. J. Smith, D. Makarov et al., “Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms”. Lab Chip (Tutorial Review) 12, 1917 (2012).
[11] G. Lin, D. Makarov et al., “Magnetic sensing platform technologies for biomedical applications”. Lab Chip (Critical Review) 17, 1884 (2017).