Publikationsrepositorium - Helmholtz-Zentrum Dresden-Rossendorf

Hemodynamic MRI is highly promising to improve treatment decisions in asymptomatic internal carotid artery stenosis (ICAS). However, treatment efficacy evaluations require clinically applicable techniques, such as dynamic susceptibility contrast (DSC) and resting-state BOLD-based evaluations of amplitude of low-frequency fluctuations (ALFF). We present data from 16 asymptomatic ICAS patients before and after treatment and 17 age-matched healthy controls measuring cerebral blood volume (CBV) and capillary transit-time heterogeneity (CTH) by DSC and ALFF with additional cognitive testing. We hypothesized recovery of hemodynamic impairments after revascularization. Our results confirmed this hypothesis for all parameters. Interestingly, at the same time cognitive function remained impaired