Publikationsrepositorium - Helmholtz-Zentrum Dresden-Rossendorf

This review article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recommendations provided in the 2015 the consensus paper on ASL. While the 2015 consensus paper provided general guidelines for clinical applications of ASL MRI, there was a lack of guidance on disease-specific parameters. Since that time, the clinical availability and o clinical demand for ASL MRI has increased. This position paper provides guidance on using ASL in specific clinical scenarios, including acute ischemic stroke and steno-occlusive disease, arteriovenous malformations and fistulas, tumors, neurodegenerative disease, pediatric applications, and seizures/epilepsy, focusing on disease-specific considerations for sequence optimization and interpretation. We present several neuroradiological applications where ASL can provide unique diagnostic information. This guidance is intended for anyone interested in using ASL in a routine clinical setting — i.e., on a single-subject basis rather than in cohort studies — building on the previous ASL consensus review.