Publikationsrepositorium - Helmholtz-Zentrum Dresden-Rossendorf
1 PublikationSlice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D.
Müller, J.; Suckert, T.; Beyreuther, E.; Schneider, M.; Boucsein, M.; Bodenstein, E.; Stolz-Kieslich, L.; Krause, M.; Neubeck, C. V.; Haase, R.; Lühr, A.; Dietrich, A.; Nexhipi, S.
Abstract
The dataset contains comprehensive image data for a total of nine mice, which underwent normal tissue brain irradiation with 90 MeV protons.
In particular, the image data comprise cone-bem computed tomographies (CBCT), Monte Carlo beam transport simulations based on those CTs, regular magnetic resonance imaging (MRI) follow-up (≥ 26 weeks), a co-aligned DSURQE mouse brain atlas and scanned whole-brain tissue sections with histochemical and immunofluorescent markers for morphology (H&E), cell nuclei (DAPI), astrocytes (GFAP), microglia (Iba1), the intermediate filament protein Nestin, proliferation (Ki67), neurons (NeuN) and oligodendrocytes (OSP).
The volumetric image data (i.e. CBCT, MRI and brain atlas) were co-aligned using the ImageJ plugin Big Warp. The CBCT data was used as spatial reference to allow for mask-based, slice-wise alignment of CBCT and light microscopy image data in 3D with the scriptable registration tool Elastix.
We provide the data in raw format and as aligned data sets, as well as their spatial transformations.
Keywords: Preclinical; Image fusion; Proton radiation; Medical imaging; Histology
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- DOI: 10.1016/j.radonc.2023.109591 cites this (Id 32124) publication
- DOI: 10.3389/fonc.2020.598360 references this (Id 32124) publication
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Slice2Volume: Fusion of multimodal medical imaging and light microscopy data …
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Slice2Volume: Fusion of multimodal medical imaging and light microscopy data …
ROBIS: 32394 is part of this (Id 32124) publication -
Late side effects in normal mouse brain tissue after proton irradiation
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Slice2Volume: Fusion of multimodal medical imaging and light microscopy data …
ROBIS: 32394 has used this (Id 32124) publication of HZDR-primary research data
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Forschungsdaten im HZDR-Daten-Repositorium RODARE
Publication date: 2022-09-21 Open access
DOI: 10.14278/rodare.557
Versions: 10.14278/rodare.1849 | 915 | 810 | 801 | 794 | 791 | 558
License: CC-BY-4.0
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Permalink: https://www.hzdr.de/publications/Publ-32124